Chemical composition, antioxidant and anti-AGEs activities of a French poplar type propolis.
Identifieur interne : 002330 ( Main/Exploration ); précédent : 002329; suivant : 002331Chemical composition, antioxidant and anti-AGEs activities of a French poplar type propolis.
Auteurs : Séverine Boisard [France] ; Anne-Marie Le Ray ; Julia Gatto ; Marie-Christine Aumond ; Patricia Blanchard ; Séverine Derbré ; Catherine Flurin ; Pascal RichommeSource :
- Journal of agricultural and food chemistry [ 1520-5118 ] ; 2014.
Descripteurs français
- KwdFr :
- Antioxydants (pharmacologie), Extraits de plantes (composition chimique), Extraits de plantes (pharmacologie), Flavanones (analyse), Flavanones (pharmacologie), Flavonoïdes (analyse), Fractionnement chimique (MeSH), Polyphénols (analyse), Populus (composition chimique), Produits terminaux de glycation avancée (antagonistes et inhibiteurs), Propolis (composition chimique), Propolis (pharmacologie).
- MESH :
- analyse : Flavanones, Flavonoïdes, Polyphénols.
- antagonistes et inhibiteurs : Produits terminaux de glycation avancée.
- composition chimique : Extraits de plantes, Populus, Propolis.
- pharmacologie : Antioxydants, Extraits de plantes, Flavanones, Propolis.
- Fractionnement chimique.
English descriptors
- KwdEn :
- Antioxidants (pharmacology), Chemical Fractionation (MeSH), Flavanones (analysis), Flavanones (pharmacology), Flavonoids (analysis), Glycation End Products, Advanced (antagonists & inhibitors), Plant Extracts (chemistry), Plant Extracts (pharmacology), Polyphenols (analysis), Populus (chemistry), Propolis (chemistry), Propolis (pharmacology).
- MESH :
- chemical , analysis : Flavanones, Flavonoids, Polyphenols.
- chemical , antagonists & inhibitors : Glycation End Products, Advanced.
- chemical , chemistry : Plant Extracts, Propolis.
- chemical , pharmacology : Antioxidants, Flavanones, Plant Extracts, Propolis.
- chemistry : Populus.
- Chemical Fractionation.
Abstract
Accumulation in tissues and serum of advanced glycation end-products (AGEs) plays an important role in pathologies such as Alzheimer's disease or, in the event of complications of diabetes, atherosclerosis or renal failure. Therefore, there is a potential therapeutic interest in compounds able to lower intra and extracellular levels of AGEs. Among them, natural antioxidants (AO) with true anti-AGEs capabilities would represent good candidates for development. The purpose of this study was to evaluate the AO and anti-AGEs potential of a propolis batch and then to identify the main compounds responsible for these effects. In vivo, protein glycation and oxidative stress are closely related. Thus, AO and antiglycation activities were evaluated using both DPPH and ORAC assays, respectively, as well as a newly developed automated anti-AGEs test. Several propolis extracts exhibited very good AO and anti-AGEs activities, and a bioguided fractionation allowed us to identify pinobanksin-3-acetate as the most active component.
DOI: 10.1021/jf4053397
PubMed: 24443994
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Therefore, there is a potential therapeutic interest in compounds able to lower intra and extracellular levels of AGEs. Among them, natural antioxidants (AO) with true anti-AGEs capabilities would represent good candidates for development. The purpose of this study was to evaluate the AO and anti-AGEs potential of a propolis batch and then to identify the main compounds responsible for these effects. In vivo, protein glycation and oxidative stress are closely related. Thus, AO and antiglycation activities were evaluated using both DPPH and ORAC assays, respectively, as well as a newly developed automated anti-AGEs test. Several propolis extracts exhibited very good AO and anti-AGEs activities, and a bioguided fractionation allowed us to identify pinobanksin-3-acetate as the most active component. </AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Boisard</LastName><ForeName>Séverine</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>EA 921 SONAS/SFR 4207 QUASAV, Université d'Angers , 16 Boulevard Daviers, 49045 Angers cedex 01, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Le Ray</LastName><ForeName>Anne-Marie</ForeName><Initials>AM</Initials></Author><Author ValidYN="Y"><LastName>Gatto</LastName><ForeName>Julia</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Aumond</LastName><ForeName>Marie-Christine</ForeName><Initials>MC</Initials></Author><Author ValidYN="Y"><LastName>Blanchard</LastName><ForeName>Patricia</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Derbré</LastName><ForeName>Séverine</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Flurin</LastName><ForeName>Catherine</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Richomme</LastName><ForeName>Pascal</ForeName><Initials>P</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>01</Month><Day>29</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Agric Food Chem</MedlineTA><NlmUniqueID>0374755</NlmUniqueID><ISSNLinking>0021-8561</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000975">Antioxidants</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance 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MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005591" MajorTopicYN="N">Chemical Fractionation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D044950" MajorTopicYN="N">Flavanones</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005419" MajorTopicYN="N">Flavonoids</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017127" MajorTopicYN="N">Glycation End Products, Advanced</DescriptorName><QualifierName UI="Q000037" MajorTopicYN="Y">antagonists & inhibitors</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010936" MajorTopicYN="N">Plant Extracts</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000494" 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first="Catherine" last="Flurin">Catherine Flurin</name><name sortKey="Gatto, Julia" sort="Gatto, Julia" uniqKey="Gatto J" first="Julia" last="Gatto">Julia Gatto</name><name sortKey="Le Ray, Anne Marie" sort="Le Ray, Anne Marie" uniqKey="Le Ray A" first="Anne-Marie" last="Le Ray">Anne-Marie Le Ray</name><name sortKey="Richomme, Pascal" sort="Richomme, Pascal" uniqKey="Richomme P" first="Pascal" last="Richomme">Pascal Richomme</name></noCountry><country name="France"><region name="Pays de la Loire"><name sortKey="Boisard, Severine" sort="Boisard, Severine" uniqKey="Boisard S" first="Séverine" last="Boisard">Séverine Boisard</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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